Article
Mutations in the activation function-2 core domain of steroidogenic factor-1 dominantly suppresses PKA-dependent transactivation of the bovine CYP17 gene.
The Journal of biological chemistry - 29 May 1998
Jacob A L, Lund J
Abstract excerpt
Steroidogenic factor-1 (SF-1) is a nuclear receptor that is essential for the proper development and function of steroid hormone-producing cells. The activation function-2 (AF-2) domain in SF-1 is a short alpha-helix in the C terminus that is conserved with respect to other nuclear receptors and...
Topics
- Animals
- COS Cells
- Cattle
- Cell Line
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Fushi Tarazu Transcription Factors
- Homeodomain Proteins
- Mice
- Mutation
- Receptors, Cytoplasmic and Nuclear
- Steroid 17-alpha-Hydroxylase
- Steroidogenic Factor 1
- Transcription Factors
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured