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Article

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2012

Deupi Xavier, Edwards Patricia, Singhal Ankita, Nickle Benjamin, Oprian Daniel, Schertler Gebhard, Standfuss Jörg

Abstract excerpt

G protein-coupled receptors (GPCR) are seven transmembrane helix proteins that couple binding of extracellular ligands to conformational changes and activation of intracellular G proteins, GPCR kinases, and arrestins. Constitutively active mutants are ubiquitously found among GPCRs and increase the inherent basal activity of the receptor, which often correlates with a pathological outcome. Here, we have used the...

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Identifiers

PMID: 22198838
DOI: 10.1073/pnas.1114089108
PMCID: PMC3252945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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