Article
Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.
Angewandte Chemie (International ed. in English) - 1 Sept 2020
Kubatova Nina, Mao Jiafei, Eckert Carl Elias, Saxena Krishna, Gande Santosh L, Wachtveitl Josef, Glaubitz Clemens, Schwalbe Harald
Abstract excerpt
The RHO gene encodes the G-protein-coupled receptor (GPCR) rhodopsin. Numerous mutations associated with impaired visual cycle have been reported; the G90D mutation leads to a constitutively active mutant form of rhodopsin that causes CSNB disease. We report on the structural investigation of the retinal configuration and conformation in the binding pocket in the dark and light-activated state by solution and...
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