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Article

Conformational selection and equilibrium governs the ability of retinals to bind opsin.

The Journal of biological chemistry - 13 Feb 2015

Schafer Christopher T, Farrens David L

Abstract excerpt

Despite extensive study, how retinal enters and exits the visual G protein-coupled receptor rhodopsin remains unclear. One clue may lie in two openings between transmembrane helix 1 (TM1) and TM7 and between TM5 and TM6 in the active receptor structure. Recently, retinal has been proposed to enter the inactive apoprotein opsin (ops) through these holes when the receptor transiently adopts the active opsin...

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Identifiers

PMID: 25451936
DOI: 10.1074/jbc.M114.603134
PMCID: PMC4326838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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