Article
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Fritze Olaf, Filipek Sławomir, Kuksa Vladimir, Palczewski Krzysztof, Hofmann Klaus Peter, Ernst Oliver P
Abstract excerpt
In the G protein-coupled receptor rhodopsin, the conserved NPxxY(x)(5,6)F motif connects the transmembrane helix VII and the cytoplasmic helix 8. The less geometrically constrained retinal analogue 9-demethyl-retinal prevents efficient transformation of rhodopsin to signaling metarhodopsin (Meta) II after retinal photoisomerization. Here, we demonstrate that Ala replacement mutations within the NPxxY(x)(5,6)F...
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