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Article

Precision vs flexibility in GPCR signaling.

Journal of the American Chemical Society - 21 Aug 2013

Elgeti Matthias, Rose Alexander S, Bartl Franz J, Hildebrand Peter W, Hofmann Klaus-Peter, Heck Martin

Abstract excerpt

The G protein coupled receptor (GPCR) rhodopsin activates the heterotrimeric G protein transducin (Gt) to transmit the light signal into retinal rod cells. The rhodopsin activity is virtually zero in the dark and jumps by more than one billion fold after photon capture. Such perfect switching implies both high fidelity and speed of rhodopsin/Gt coupling. We employed Fourier transform infrared (FTIR) spectroscopy...

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PMID: 23883288
DOI: 10.1021/ja405133k

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