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Article

Diagnostic accuracy of high resolution melting analysis for detection of KRAS mutations: a systematic review and meta-analysis.

Scientific reports - 17 Dec 2014

Liu Yue-Ping, Wu Hai-Yan, Yang Xiang, Xu Han-Qing, Chen Dong, Huang Qing, Fu Wei-Ling

Abstract excerpt

Increasing evidence points to a negative correlation between KRAS mutations and patients' responses to anti-EGFR monoclonal antibody treatment. Therefore, patients must undergo KRAS mutation detection to be eligible for treatment. High resolution melting analysis (HRM) is gaining increasing attention in KRAS mutation detection. However, its accuracy has not been systematically evaluated. We conducted a...

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Identifiers

PMID: 25515911
DOI: 10.1038/srep07521
PMCID: PMC4268648

Genes

KRAS
EGFR

Provenance

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