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Article

High-resolution melting analysis for accurate detection of BRAF mutations: a systematic review and meta-analysis.

Scientific reports - 25 Feb 2014

Chen Dong, Wang Yan-Yan, Chuai Zheng-Ran, Huang Jun-Fu, Wang Yun-Xia, Liu Kai, Zhang Li-Qun, Yang Zhao, Shi Da-Chuan, Liu Qian, Huang Qing, Fu Wei-Ling

Abstract excerpt

The high-resolution melting curve analysis (HRMA) might be a good alternative method for rapid detection of BRAF mutations. However, the accuracy of HRMA in detection of BRAF mutations has not been systematically evaluated. We performed a systematic review and meta-analysis involving 1324 samples from 14 separate studies. The overall sensitivity of HRMA was 0.99 (95% confidence interval (CI) = 0.75-0.82), and the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24566771
DOI: 10.1038/srep04168
PMCID: PMC3933866

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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