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Article

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jul 2012

Varadé Jezabel, Comabella Manuel, Ortiz Miguel A, Arroyo Rafael, Fernández Oscar, Pinto-Medel M Jesús, Fedetz María, Izquierdo Guillermo, Lucas Miguel, Gómez Carlos López, Rabasa Antonio Catalá, Alcina Antonio, Matesanz Fuencisla, Alloza Iraide, Antigüedad Alfredo, García-Barcina María, Otaegui David, Olascoaga Javier, Saiz Albert, Blanco Yolanda, Montalbán Xavier, Vandenbroeck Koen, Urcelay Elena

Abstract excerpt

BACKGROUND AND OBJECTIVES: Ten genes previously showing different evidence of association with multiple sclerosis have been selected to validate. METHODS: Eleven polymorphisms were genotyped with the iPLEX™ Sequenom in a well-powered collection of Spanish origin including 2863 multiple sclerosis cases and 2930 controls. RESULTS: Replication extended to the following polymorphisms: PKN2 (rs305217), GTF2B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adaptor Proteins, Signal Transducing
Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study
Share to Interleukin-12 Subunit p40
Share to Membrane Proteins
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Share to Polymorphism, Single Nucleotide
Share to Proto-Oncogene Proteins c-cbl

Source

Identifiers

PMID: 22194214
DOI: 10.1177/1352458511432741

Genes

CBLB
CNR1
EPHA4
PKN2
PTPRM
YTHDF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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