Article
Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
Human molecular genetics - 1 Mar 2010
Abstract excerpt
Genome-wide association studies (GWASs) have proven highly effective, identifying hundreds of associations across numerous complex diseases. These studies typically test hundreds of thousands of variations and identify hundreds of potential associations. However, to date, follow-up attempts have generally only concentrated on just the few most significant initial associations, leaving the majority of true...
Topics
- Case-Control Studies
- Disease Susceptibility
- Follow-Up Studies
- Genome, Human
- Genome-Wide Association Study
- Genotype
- Humans
- Kinesins
- Membrane Proteins
- Multiple Sclerosis
- Polymorphism, Single Nucleotide