Article
Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.
Genes and immunity - 1 Mar 2011
Cavanillas M L, Fernández O, Comabella M, Alcina A, Fedetz M, Izquierdo G, Lucas M, Cénit M C, Arroyo R, Vandenbroeck K, Alloza I, García-Barcina M, Antigüedad A, Leyva L, Gómez C L, Olascoaga J, Otaegui D, Blanco Y, Saiz A, Montalbán X, Matesanz F, Urcelay E
Abstract excerpt
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with presumed autoimmune origin, triggered by genetic and environmental risk factors. A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306...
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