Article
Influence of Arg72Pro polymorphisms of TP53 on the response of buccal cells to radiotherapy.
Genetics and molecular research : GMR - 14 Dec 2011
Pereira L, Carvalho M R S, Fonseca C G, Lima S S S, Cerqueira E M M, Jorge W, Castro M C L
Abstract excerpt
Polymorphisms in the TP53 gene codon 72 (Arg72Pro) influence apoptosis induction and DNA damage repair. We evaluated how variants of protein p53 (p53Arg and p53Pro) affect cell death and DNA damage repair by analyzing the frequencies of karyorrhexis and micronuclei. There were significant differences in the frequency of karyorrhexis between the three p53 genotypes (Arg/Arg, Arg/Pro, and Pro/Pro), between...
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