Article
Contribution of polymorphism in codon 72 of TP53 gene to laryngeal cancer in Polish patients.
Oral oncology - 1 Aug 2009
Zemleduch Tomasz, Lianeri Margarita, Rydzanicz Małgorzata, Gajecka Marzena, Szyfter Krzysztof, Jagodziński Paweł P
Abstract excerpt
The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patients with laryngeal...
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