Article
p53 polymorphic variants at codon 72 and the outcome of therapy in randomized breast cancer patients.
Pharmacogenetics and genomics - 1 May 2006
Wegman Pia, Stal Olle, Askmalm Marie Stenmark, Nordenskjöld Bo, Rutqvist Lars-Erik, Wingren Sten
Abstract excerpt
BACKGROUND: Adjuvant therapy of breast cancer patients reduces the risk of recurrence and mortality, although, a substantial proportion of patients acquire resistance and relapse in the disease. Predictors of therapeutic response are therefore important to avoid both therapy resistance and the side effects of inefficient regimes. The p53 protein is a key determinant to induce either growth arrest or apoptosis in...
Topics
- Alleles
- Antineoplastic Agents, Hormonal
- Breast Neoplasms
- Chemotherapy, Adjuvant
- Codon
- Female
- Genes, p53
- Genetic Variation
- Humans
- Polymorphism, Genetic
- Radiotherapy, Adjuvant