Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.

Journal of neurochemistry - 1 Mar 2011

Grimm Marcus O W, Kuchenbecker Johanna, Rothhaar Tatjana L, Grösgen Sven, Hundsdörfer Benjamin, Burg Verena K, Friess Petra, Müller Ulrike, Grimm Heike S, Riemenschneider Mathias, Hartmann Tobias

Abstract excerpt

Lipids play an important role as risk or protective factors in Alzheimer's disease, which is characterized by amyloid plaques composed of aggregated amyloid-beta. Plasmalogens are major brain lipids and controversially discussed to be altered in Alzheimer's disease (AD) and whether changes in plasmalogens are cause or consequence of AD pathology. Here, we reveal a new physiological function of the amyloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Alkyl and Aryl Transferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Amyloid beta-Protein Precursor

Share to Cytidine Deaminase

Share to Neuroblastoma

Share to Oxidative Stress

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 21214572
DOI: 10.1111/j.1471-4159.2010.07070.x

Genes

APP
AGPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.PMID 21214572Read ↗

Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s diseaseSemantic proximity Read ↗

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.Semantic proximity Read ↗

Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease.Semantic proximity Read ↗

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.Semantic proximity Read ↗

Lipidomic Fingerprints Reveal Sex-, Age-, and Disease-Dependent Differences in the TgF344-AD Transgenic RatsSemantic proximity Read ↗

Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.Semantic proximity Read ↗

[The role of lipids in the pathogenesis of lateral amyotrophic sclerosis].Semantic proximity Read ↗

Ethanol Alters APP Processing and Aggravates Alzheimer-Associated PhenotypesSemantic proximity Read ↗

[The role of cholesterol in Alzheimer's neuro-pathogenesis].Semantic proximity Read ↗

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.Semantic proximity Read ↗

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model miceSemantic proximity Read ↗

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.