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Article

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

30 Jul 2018

Abstract excerpt

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine kinase, which senses and integrates several intracellular and environmental cues to orchestrate major processes such as cell growth and metabolism. Altered mTOR signalling is associated with brain malformation and neurological disorders. Emerging evidence indicates that even subtle defects in the mTOR pathway may produce severe...

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PMID: 30061532
DOI: 10.3390/ijms19082226

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