Article
mTOR Signaling in Parkinson's Disease.
Neuromolecular medicine - 1 Mar 2017
Lan Ai-Ping, Chen Jun, Zhao Yuliang, Chai Zhifang, Hu Yi
Abstract excerpt
As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson's disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent...
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