Article
Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion.
Scientific reports - 20 Jul 2015
Ghiglieri Veronica, Napolitano Francesco, Pelosi Barbara, Schepisi Chiara, Migliarini Sara, Di Maio Anna, Pendolino Valentina, Mancini Maria, Sciamanna Giuseppe, Vitucci Daniela, Maddaloni Giacomo, Giampà Carmela, Errico Francesco, Nisticò Robert, Pasqualetti Massimo, Picconi Barbara, Usiello Alessandro
Abstract excerpt
Mechanisms of gender-specific synaptic plasticity in the striatum, a brain region that controls motor, cognitive and psychiatric functions, remain unclear. Here we report that Rhes, a GTPase enriched in medium spiny neurons (MSNs) of striatum, alters the striatal cAMP/PKA signaling cascade in a gender-specific manner. While Rhes knockout (KO) male mice, compared to wild-type (WT) mice, had a significant basal...
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