Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients.

doi:10.1371/journal.pone.0028617

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Article

Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients.

PloS one - 1 Jan 2011

Miyamura Tatsuo, Kanda Tatsuo, Nakamoto Shingo, Wu Shuang, Fujiwara Keiichi, Imazeki Fumio, Yokosuka Osamu

Abstract excerpt

BACKGROUND: We investigated associations between signal transducer and activator of transcription (STAT) 1 in pretreated liver tissues, interleukin (IL) 28B polymorphism and treatment response in hepatitis C virus (HCV)-infected patients treated with peginterferon and ribavirin. METHODS AND FINDINGS: We performed immunostaining analysis of STAT1 in liver tissues and determined IL28B polymorphism at rs8099917. We...

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PMID: 22174846
DOI: 10.1371/journal.pone.0028617
PMCID: PMC3236206

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STAT1

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