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Article

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection.

Gastroenterology - 1 Mar 2010

Chen Limin, Borozan Ivan, Sun Jing, Guindi Maha, Fischer Sandra, Feld Jordan, Anand Nitasha, Heathcote Jenny, Edwards Aled M, McGilvray Ian D

Abstract excerpt

BACKGROUND & AIMS: Chronic hepatitis C virus (CHC) infection is treated with interferon/ribavirin, but only a subset of patients respond. Treatment nonresponders have marked pretreatment up-regulation of a subset of interferon stimulated genes (ISGs) in their livers, including ISG15. We here study how the nonresponder gene expression phenotype is influenced by clinical factors and uncover the cellular basis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19900446
DOI: 10.1053/j.gastro.2009.10.046

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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