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Article

Temperature rise after peginterferon alfa-2a injection in patients with chronic hepatitis C is associated with virological response and is modulated by IL28B genotype.

Journal of hepatology - 1 Nov 2013

Han Hwalih, Noureddin Mazen, Witthaus Michael, Park Yoon J, Hoofnagle Jay H, Liang T Jake, Rotman Yaron

Abstract excerpt

BACKGROUND & AIMS: Interferon treatment for chronic hepatitis C is associated with non-specific symptoms including fever. We aimed to determine the association of temperature changes with interferon antiviral activity. METHODS: 60 treatment-naïve patients with chronic hepatitis C (67% genotype 1/4/6, 33% genotype 2/3) were admitted to start peginterferon alfa-2a and ribavirin in a clinical trial. Temperature was...

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Identifiers

PMID: 23850879
DOI: 10.1016/j.jhep.2013.07.004
PMCID: PMC3856983

Genes

CXCL10
ISG15
RSAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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