Article
Liver interleukin-8 messenger RNA expression and interferon sensitivity-determining region mutations relate to treatment response in hepatitis C 1b.
Antiviral therapy - 1 Jan 2011
Lee Chuan-Mo, Yen Yi-Hao, Hung Chao-Hung, Lu Sheng-Nan, Wang Jing-Houng, Wang Jyh-Chwan, Chen Chien-Hung, Kee Kwong-Ming, Hu Tsung-Hui, Changchien Chi-Sin
Abstract excerpt
BACKGROUND: In vitro study has shown that mechanisms for inhibiting interferon (IFN)-α antiviral action by non-structural 5A protein include interaction with IFN-induced RNA-dependent protein kinase and induction of interleukin (IL)-8 expression. Mutations in the non-structural 5A IFN sensitivity-determining region (ISDR) were reported to correlate with sustained virological response (SVR). IL-8 is associated...
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