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Article

Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.

Oncogene - 18 Mar 2010

Kohler E M, Brauburger K, Behrens J, Schneikert J

Abstract excerpt

The adenomatous polyposis coli (APC) protein is a negative regulator of the mitogenic transcription factor beta-catenin by stimulating its proteasomal degradation. This involves several APC domains, including the binding sites for axin/conductin, the recently described beta-Catenin Inhibitory Domain (CID) and the third 20 amino acid repeat (20R3) that is a beta-catenin-binding site. The four 15 amino acid repeats...

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Source

Identifiers

PMID: 19966865
DOI: 10.1038/onc.2009.447

Genes

APC
FAP

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