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Article

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.

Human molecular genetics - 15 Jan 2007

Schneikert Jean, Grohmann Annette, Behrens Jürgen

Abstract excerpt

Most colon cancer cells express truncated versions of the tumour suppressor Adenomatous Polyposis Coli (APC). These molecules are selected during tumourigenesis for impaired beta-catenin degrading activity. In this study, we describe that truncated APC can still control the activity of beta-catenin in colon cancer cell lines via its first 20 amino acid repeat. First, we show that both endogenous and ectopically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17189293
DOI: 10.1093/hmg/ddl464

Genes

APC
AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.PMID 17189293Read ↗

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gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

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The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.Semantic proximity Read ↗

Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells.Semantic proximity Read ↗

APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.Semantic proximity Read ↗

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