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Article

Amino acid variations in hepatitis C virus p7 and sensitivity to antiviral combination therapy with amantadine in chronic hepatitis C.

Antiviral therapy - 1 Jan 2006

Mihm Ulrike, Grigorian Natalia, Welsch Christoph, Herrmann Eva, Kronenberger Bernd, Teuber Gerlinde, von Wagner Michael, Hofmann Wolf-Peter, Albrecht Mario, Lengauer Thomas, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND: Formation of transmembrane ion channels by hepatitis C virus (HCV) p7 and abrogation of channel function by amantadine was demonstrated in vitro. The relevance of HCV p7 amino acid (aa) variations for response to antiviral therapy with amantadine is unknown. METHODS: HCV p7 was sequenced in 86 individuals who were infected with HCV genotype 1. Thirty-six of 86 patients received amantadine within an...

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PMID: 16856625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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