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Article

Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time.

PloS one - 5 May 2011

Li Hui, Hughes Austin L, Bano Nazneen, McArdle Susan, Livingston Stephen, Deubner Heike, McMahon Brian J, Townshend-Bulson Lisa, McMahan Rachel, Rosen Hugo R, Gretch David R

Abstract excerpt

Infection with hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and end-stage liver disease worldwide. The genetics of HCV infection in humans and the disease course of chronic hepatitis C are both remarkably variable. Although the response to interferon treatment is largely dependent on HCV genotypes, whether or not a relationship exists between HCV genome variability...

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Identifiers

PMID: 21573177
DOI: 10.1371/journal.pone.0019562
PMCID: PMC3088699

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Source receipt: pubmed, retrieved 7 Sept 2026.

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