Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev.

doi:10.1016/0042-6822(90)90242-j

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Article

Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev.

Virology - 1 May 1990

Subramanian T, Kuppuswamy M, Venkatesh L, Srinivasan A, Chinnadurai G

Abstract excerpt

The tat gene of HIV is a strong activator of the viral LTR. The Tat protein contains a highly basic domain that is important for its transport to the nuclear/nucleolar locations. The Tat basic domain when fused to Escherichia coli beta-galactosidase directed the chimeric protein to the nucleus an...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Cloning, Molecular
Gene Products, rev
Genes, Viral
Genes, tat
HIV-1
Molecular Sequence Data
Mutation
Nucleolus Organizer Region
Regulatory Sequences, Nucleic Acid
Signal Transduction
Trans-Activators
Transcriptional Activation
rev Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 2184574
DOI: 10.1016/0042-6822(90)90242-j

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2184574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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