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Article

Use of the gamma method for self-contained gene-set analysis of SNP data.

European journal of human genetics : EJHG - 1 May 2012

Biernacka Joanna M, Jenkins Gregory D, Wang Liewei, Moyer Ann M, Fridley Brooke L

Abstract excerpt

Gene-set analysis (GSA) evaluates the overall evidence of association between a phenotype and all genotyped single nucleotide polymorphisms (SNPs) in a set of genes, as opposed to testing for association between a phenotype and each SNP individually. We propose using the Gamma Method (GM) to combine gene-level P-values for assessing the significance of GS association. We performed simulations to compare the GM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22166939
DOI: 10.1038/ejhg.2011.236
PMCID: PMC3330217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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