Adaptive Set-Based Methods for Association Testing.

Abstract excerpt

With a typical sample size of a few thousand subjects, a single genome-wide association study (GWAS) using traditional one single nucleotide polymorphism (SNP)-at-a-time methods can only detect genetic variants conferring a sizable effect on disease risk. Set-based methods, which analyze sets of SNPs jointly, can detect variants with smaller effects acting within a gene, a pathway, or other biologically relevant...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Risk
• Share to Computer Simulation
• Share to Genetic Predisposition to Disease