Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATES: a rapid and powerful gene-based association test using extended Simes procedure.

American journal of human genetics - 11 Mar 2011

Li Miao-Xin, Gui Hong-Sheng, Kwan Johnny S H, Sham Pak C

Abstract excerpt

The gene has been proposed as an attractive unit of analysis for association studies, but a simple yet valid, powerful, and sufficiently fast method of evaluating the statistical significance of all genes in large, genome-wide datasets has been lacking. Here we propose the use of an extended Simes test that integrates functional information and association evidence to combine the p values of the single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Crohn Disease
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 21397060
DOI: 10.1016/j.ajhg.2011.01.019
PMCID: PMC3059433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATES: a rapid and powerful gene-based association test using extended Simes procedure.PMID 21397060Read ↗

HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.Semantic proximity Read ↗

On optimal gene-based analysis of genome scans.Semantic proximity Read ↗

MGAS: a powerful tool for multivariate gene-based genome-wide association analysis.Semantic proximity Read ↗

FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics.Semantic proximity Read ↗

FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and AffiliationsSemantic proximity Read ↗

COMBAT: A Combined Association Test for Genes Using Summary Statistics.Semantic proximity Read ↗

TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies.Semantic proximity Read ↗

SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases.Semantic proximity Read ↗

Cauchy combination methods for the detection of gene-environment interactions for rare variants related to quantitative phenotypes.Semantic proximity Read ↗

Gene-based testing of interactions in association studies of quantitative traits.Semantic proximity Read ↗

Resampling-based multiple hypothesis testing procedures for genetic case-control association studies.Semantic proximity Read ↗

Powerful Set-Based Gene-Environment Interaction Testing Framework for Complex Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.