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Article

Efficient and Powerful Method for Combining P-Values in Genome-Wide Association Studies.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Nov 2016

Vilor-Tejedor Natalia, Gonzalez Juan R, Calle M Luz

Abstract excerpt

The goal of Genome-wide Association Studies (GWAS) is the identification of genetic variants, usually single nucleotide polymorphisms (SNPs), that are associated with disease risk. However, SNPs detected so far with GWAS for most common diseases only explain a small proportion of their total heritability. Gene set analysis (GSA) has been proposed as an alternative to single-SNP analysis with the aim of improving...

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PMID: 28055892
DOI: 10.1109/TCBB.2015.2509977

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