Article
META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies.
PloS one - 1 Jan 2015
Rosenberger Albert, Friedrichs Stefanie, Amos Christopher I, Brennan Paul, Fehringer Gordon, Heinrich Joachim, Hung Rayjean J, Muley Thomas, Müller-Nurasyid Martina, Risch Angela, Bickeböller Heike
Abstract excerpt
INTRODUCTION: Gene-set analysis (GSA) methods are used as complementary approaches to genome-wide association studies (GWASs). The single marker association estimates of a predefined set of genes are either contrasted with those of all remaining genes or with a null non-associated background. To pool the p-values from several GSAs, it is important to take into account the concordance of the observed patterns...
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