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Article

Disruption of lens fiber cell architecture in mice expressing a chimeric AQP0-LTR protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2000

Shiels A, Mackay D, Bassnett S, Al-Ghoul K, Kuszak J

Abstract excerpt

Aquaporin-0 (AQP0) is the major intrinsic protein of lens fiber cells and the founder member of the water channel gene family. Here we show that disruption of the AQP0 gene by an early transposon (ETn) element results in expression of a chimeric protein, comprised of approximately 75% AQP0 and approximately 25% ETn long terminal repeat (LTR) sequence, in the cataract Fraser (CatFr) mouse lens. Immunoblot analysis...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11053241
DOI: 10.1096/fj.99-1071com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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