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Article

An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.

Developmental biology - 15 Feb 2014

Eroglu Binnur, Min Jin-Na, Zhang Yan, Szurek Edyta, Moskophidis Demetrius, Eroglu Ali, Mivechi Nahid F

Abstract excerpt

Heat shock factor binding protein 1 (HSBP1) is a 76 amino acid polypeptide that contains two arrays of hydrophobic heptad repeats and was originally identified through its interaction with the oligomerization domain of heat shock factor 1 (Hsf1), suppressing Hsf1's transcriptional activity following stress. To examine the function of HSBP1 in vivo, we generated mice with targeted disruption of the hsbp1 gene and...

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Identifiers

PMID: 24380799
DOI: 10.1016/j.ydbio.2013.12.038
PMCID: PMC4114229

Genes

HSBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.PMID 24380799Read ↗

Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish.Semantic proximity Read ↗

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice.Semantic proximity Read ↗

Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis.Semantic proximity Read ↗

Maintenance of Olfactory Neurogenesis Requires HSF1, a Major Heat Shock Transcription Factor in MiceSemantic proximity Read ↗

<i>Caenorhabditis elegans </i><scp>HSF</scp>‐1 is an essential nuclear protein that forms stress granule‐like structures following heat shockSemantic proximity Read ↗

Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis.Semantic proximity Read ↗

Heat shock transcription factors and sensory placode development.Semantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

HSF1 functions as a transcription regulator for Dp71 expression.Semantic proximity Read ↗

Heat shock factor 1 protects germ cell proliferation during early ovarian differentiation in medakaSemantic proximity Read ↗

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Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures.Semantic proximity Read ↗

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