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Article

Defect of LSS Disrupts Lens Development in Cataractogenesis

2 Dec 2021

Abstract excerpt

Congenital cataract is one of the leading causes of blindness in children worldwide. About one-third of congenital cataracts are caused by genetic defects. LSS, which encodes lanosterol synthase, is a causal gene for congenital cataracts. LSS is critical in preventing abnormal protein aggregation of various cataract-causing mutant crystallins; however, its roles in lens development remain largely unknown. In our...

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PMID: 34926465
DOI: 10.3389/fcell.2021.788422

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