Article
Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.
In vivo (Athens, Greece) - 1 Jan 2000
Wiles Walter Guy, Mou Zhongming, Du Yang, Long Alyssa B, Scharer Christopher D, Bilir Birdal, Spyropoulos Demetri D, Jenkins Nancy A, Copeland Neal G, Martin W David, Moreno Carlos S
Abstract excerpt
BACKGROUND: Sox4 is an essential gene, and genetic deletion results in embryonic lethality. In an effort to develop mice with tissue-specific deletion, we bred conditional knockout mice bearing LoxP recombination sites flanking the Sox4 gene, with the LoxP sites located in the Sox4 5'UTR and 3'UTR. RESULTS: The number of mice homozygous for this LoxP-flanked conditional knockout allele was far below the expected...
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