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Article

AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice.

BMC ophthalmology - 20 Jul 2009

Andley Usha P

Abstract excerpt

BACKGROUND: AlphaA-crystallin (CRYAA/HSPB4), a major component of all vertebrate eye lenses, is a small heat shock protein responsible for maintaining lens transparency. The R49C mutation in the alphaA-crystallin protein is linked with non-syndromic, hereditary human cataracts in a four-generation Caucasian family. METHODS: This study describes a mouse cataract model generated by insertion of a neomycin-resistant...

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Identifiers

PMID: 19619312
DOI: 10.1186/1471-2415-9-4
PMCID: PMC2724435

Genes

CRYAA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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