Article
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
Blood - 9 Feb 2012
Frisan Emilie, Vandekerckhove Julie, de Thonel Aurélie, Pierre-Eugène Cécile, Sternberg Alexander, Arlet Jean-Benoît, Floquet Célia, Gyan Emmanuel, Kosmider Olivier, Dreyfus François, Gabet Anne-Sophie, Courtois Geneviève, Vyas Paresh, Ribeil Jean-Antoine, Zermati Yael, Lacombe Catherine, Mayeux Patrick, Solary Eric, Garrido Carmen, Hermine Olivier, Fontenay Michaela
Abstract excerpt
Normal human erythroid cell maturation requests the transcription factor GATA-1 and a transient activation of caspase-3, with GATA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock protein 70 (Hsp70) in the nucleus. Erythroid cell dysplasia observed in early myelodysplastic syndromes (MDS) involves impairment of differentiation and excess of apoptosis with a burst of...
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