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Article

Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis

4 Oct 2011

Abstract excerpt

Myelodysplastic syndromes (MDS) are characterized by dyserythropoiesis resulting in anemia. This pathological hallmark is incompletely understood. Notch signaling has been linked to impaired erythropoietic and megakaryopoietic development of CD34+ progenitor cells, but its role in MDS is unclear. We have analyzed the transcriptional activity of Notch pathway elements and its association with the key erythroid...

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PMID: 21967505
DOI: 10.1111/j.1600-0609.2011.01715.x

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