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Article

Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation.

Developmental cell - 23 Dec 2013

Elagib Kamaleldin E, Rubinstein Jeremy D, Delehanty Lorrie L, Ngoh Valerie S, Greer Peter A, Li Shuran, Lee Jae K, Li Zhe, Orkin Stuart H, Mihaylov Ivailo S, Goldfarb Adam N

Abstract excerpt

Megakaryocyte morphogenesis employs a "hypertrophy-like" developmental program that is dependent on P-TEFb kinase activation and cytoskeletal remodeling. P-TEFb activation classically occurs by a feedback-regulated process of signal-induced, reversible release of active Cdk9-cyclin T modules from large, inactive 7SK small nuclear ribonucleoprotein particle (snRNP) complexes. Here, we have identified an...

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Identifiers

PMID: 24369834
DOI: 10.1016/j.devcel.2013.11.013
PMCID: PMC3892434

Genes

GATA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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