Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish.

Experimental hematology - 1 Sept 2016

De La Garza Adriana, Cameron Rosannah C, Nik Sara, Payne Sara G, Bowman Teresa V

Abstract excerpt

SF3B1 (Splicing factor 3b, subunit 1) is one of the most commonly mutated factors in myelodysplastic syndrome (MDS). Although the genetic correlation between SF3B1 mutations and MDS etiology are quite strong, no in vivo model currently exists to explore how SF3B1 loss alters blood cell development. Using zebrafish mutants, we show here that proper function of Sf3b1 is required for all hematopoietic lineages. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythroid Cells
Share to Hematopoiesis
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Cells

Share to Receptors, Notch

Share to RNA Splicing Factors

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27260753
DOI: 10.1016/j.exphem.2016.05.012
PMCID: PMC4992596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spliceosomal component Sf3b1 is essential for hematopoietic differentiation in zebrafish.PMID 27260753Read ↗

Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts.Semantic proximity Read ↗

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.Semantic proximity Read ↗

Use of the zebrafish system to study primitive and definitive hematopoiesis.Semantic proximity Read ↗

Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.Semantic proximity Read ↗

Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.Semantic proximity Read ↗

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafishSemantic proximity Read ↗

Modeling hematopoietic disorders in zebrafishSemantic proximity Read ↗

Zebrafish as a model of human hematologic disorders.Semantic proximity Read ↗

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasiaSemantic proximity Read ↗

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDSSemantic proximity Read ↗

Developmental biology of zebrafish myeloid cells.Semantic proximity Read ↗

The role of meis1 in primitive and definitive hematopoiesis during zebrafish developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.