Article
cpsf1 is required for definitive HSC survival in zebrafish.
Blood - 14 Apr 2011
Bolli Niccolò, Payne Elspeth M, Rhodes Jennifer, Gjini Evisa, Johnston Adam B, Guo Feng, Lee Jeong-Soo, Stewart Rodney A, Kanki John P, Chen Aye T, Zhou Yi, Zon Leonard I, Look A Thomas
Abstract excerpt
A comprehensive understanding of the genes and pathways regulating hematopoiesis is needed to identify genes causally related to bone marrow failure syndromes, myelodysplastic syndromes, and hematopoietic neoplasms. To identify novel genes involved in hematopoiesis, we performed an ethyl-nitrosourea mutagenesis screen in zebrafish (Danio rerio) to search for mutants with defective definitive hematopoiesis. We...
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