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Endothelial stiffening induced by CD36-mediated lipid uptake leads to endothelial barrier disruption and contributes to atherosclerotic lesions

2023-11-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> To determine the impact of endothelial stiffening induced by CD36-mediated lipid uptake in the disruption of aortic endothelial barrier and development of atherosclerosis in mouse models of obesity and hypercholesterolemia. <h4>Approach and Results</h4> Endothelial-specific inducible downregulation of CD36 results in abrogating the stiffening of aortic endothelium induced b...

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Literature Corpus work
db046a57-e84a-583e-aa8d-96ff1657464e
DOI
10.1101/2023.11.08.566338
Open publication

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Endothelial stiffening induced by CD36-mediated lipid uptake leads to endothelial barrier disruption and contributes to atherosclerotic lesionsDOI 10.1101/2023.11.08.566338
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