Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filaggrin and the great epidermal barrier grief.

The Australasian journal of dermatology - 1 May 2008

McGrath John A

Abstract excerpt

One of the principal functions of human skin is to form an effective mechanical barrier against the external environment. This involves the maturation and death of epidermal keratinocytes as well as the assembly of a complex network of differentially and spatially expressed proteins, glycoproteins and lipids into the keratinocyte cell membrane and surrounding extracellular space. In 2006, the key role of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Dermatitis, Atopic
Share to Epidermis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Filaggrin Proteins

Share to Hypersensitivity

Share to Intermediate Filament Proteins

Share to Keratinocytes

Share to Skin Diseases

Source

Identifiers

PMID: 18412804
DOI: 10.1111/j.1440-0960.2008.00443.x

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filaggrin and the great epidermal barrier grief.PMID 18412804Read ↗

Filaggrin in the frontline: role in skin barrier function and diseaseSemantic proximity Read ↗

One remarkable molecule: filaggrin.Semantic proximity Read ↗

Atopic eczema and the filaggrin story.Semantic proximity Read ↗

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyondSemantic proximity Read ↗

The role of filaggrin in the skin barrier and disease development.Semantic proximity Read ↗

Filaggrin loss-of-function mutations and association with allergic diseases.Semantic proximity Read ↗

Revisiting the Roles of Filaggrin in Atopic DermatitisSemantic proximity Read ↗

Filaggrin in atopic dermatitis.Semantic proximity Read ↗

[Filaggrin gene mutations are frequent and increase the risk of skin disease].Semantic proximity Read ↗

The multifunctional role of filaggrin in allergic skin disease.Semantic proximity Read ↗

Filaggrin gene defects and the risk of developing allergic disorders.Semantic proximity Read ↗

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.