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Article

The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2012

Polonikov Alexey V, Vialykh Ekaterina K, Churnosov Mikhail I, Illig Thomas, Freidin Maxim B, Vasil'eva Oksana V, Bushueva Olga Yu, Ryzhaeva Valentina N, Bulgakova Irina V, Solodilova Maria A

Abstract excerpt

In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH). A total of 667 unrelated EH patients of Russian origin, including 306 hypertensives (the EH-CS group) who suffered from CS...

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Source

Identifiers

PMID: 22158110
DOI: 10.1038/hr.2011.213

Genes

GPX4
GPX1
GPX3

Variants

rs1050450
rs1050450
rs1050450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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