The GPX3 rs3828599 genotype in combination with alcohol consumption and age helps identify a high-risk hypertension subgroup for antioxidant intervention.

doi:10.1186/s12967-025-07243-2

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Article

The GPX3 rs3828599 genotype in combination with alcohol consumption and age helps identify a high-risk hypertension subgroup for antioxidant intervention.

Journal of translational medicine - 28 Oct 2025

Xie Zhongjie, Wu Baogang, Chen Yanli, Sun Yingxian, Hao Ying

Abstract excerpt

BACKGROUND: Essential hypertension involves complex gene–environment interactions. Identifying high-risk subgroups for targeted intervention remains a challenge in hypertension prevention. We hypothesized that integrating the GPX3 rs3828599 polymorphism with environmental risk factors could stratify individuals to warrant precision antioxidant-based prevention. METHODS: In a rural Han Chinese case‒control...

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PMID: 41152890
DOI: 10.1186/s12967-025-07243-2
PMCID: PMC12570826

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GPX3

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