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Article

Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children.

Stroke - 1 Jan 2007

Voetsch Barbara, Jin Richard C, Bierl Charlene, Benke Kelly S, Kenet Gili, Simioni Paolo, Ottaviano Filomena, Damasceno Benito P, Annichino-Bizacchi Joyce M, Handy Diane E, Loscalzo Joseph

Abstract excerpt

BACKGROUND AND PURPOSE: Plasma glutathione peroxidase (GPx-3)-deficiency increases extracellular oxidant stress, decreases bioavailable nitric oxide, and promotes platelet activation. The aim of this study is to identify polymorphisms in the GPx-3 gene, examine their relationship to arterial isch...

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Source

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Identifiers

PMID: 17122425
DOI: 10.1161/01.STR.0000252027.53766.2b
PMCID: PMC1781064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17122425-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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