Article
Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2005
McBride Martin W, Brosnan M Julia, Mathers Joanne, McLellan Lesley I, Miller William H, Graham Delyth, Hanlon Neil, Hamilton Carlene A, Polke James M, Lee Wai K, Dominiczak Anna F
Abstract excerpt
Human essential hypertension is a classic example of a complex, multifactorial, polygenic disease with a substantial genetic influence in which the underlying genetic components remain unknown. The stroke-prone spontaneously hypertension rat (SHRSP) is a well-characterized experimental model for essential hypertension and endothelial dysfunction. Previous work, identified glutathione S-transferase mu type 1, a...
Topics
- Amino Acid Sequence
- Animals
- Aorta
- Arginine
- Blotting, Western
- Computer Systems
- Genetic Predisposition to Disease
- Glutathione Transferase
- Histidine
- Hypertension
- Immunohistochemistry
- Kidney
- Molecular Sequence Data