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Article

Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2005

McBride Martin W, Brosnan M Julia, Mathers Joanne, McLellan Lesley I, Miller William H, Graham Delyth, Hanlon Neil, Hamilton Carlene A, Polke James M, Lee Wai K, Dominiczak Anna F

Abstract excerpt

Human essential hypertension is a classic example of a complex, multifactorial, polygenic disease with a substantial genetic influence in which the underlying genetic components remain unknown. The stroke-prone spontaneously hypertension rat (SHRSP) is a well-characterized experimental model for essential hypertension and endothelial dysfunction. Previous work, identified glutathione S-transferase mu type 1, a...

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PMID: 15699453
DOI: 10.1161/01.HYP.0000154879.49245.39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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