Article
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2012
Lu Aiping, Proto Jonathan D, Guo Lulin, Tang Ying, Lavasani Mitra, Tilstra Jeremy S, Niedernhofer Laura J, Wang Bing, Guttridge Denis C, Robbins Paul D, Huard Johnny
Abstract excerpt
Inhibition of the inhibitor of kappa B kinase (IKK)/nuclear factor-kappa B (NF-κB) pathway enhances muscle regeneration in injured and diseased skeletal muscle, but it is unclear exactly how this pathway contributes to the regeneration process. In this study, we examined the role of NF-κB in regulating the proliferation and differentiation of muscle-derived stem cells (MDSCs). MDSCs isolated from the skeletal...
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