Exploring the positive and negative consequences of NF-kappaB inhibition for the treatment of human disease.

doi:10.4161/cc.5.11.2773

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Article

Exploring the positive and negative consequences of NF-kappaB inhibition for the treatment of human disease.

Cell cycle (Georgetown, Tex.) - 1 Jun 2006

Fraser Christopher C

Abstract excerpt

The NF-kappaB (NF-kappaB) transcription factor-signaling pathway has become a major focus for research aimed at understanding its role in development, maintenance and progression of disease. A large body of recent research suggests inhibition of NF-kappaB blocks inflammation, cancer development and progression, diabetes, stroke, muscle wasting, and other diseases. The enormous potential for the treatment of...

Topics

Drug Therapy
Drug-Related Side Effects and Adverse Reactions
Homeostasis
Humans
Inflammation
Mutation
NF-kappa B
Neoplasms
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 16721061
DOI: 10.4161/cc.5.11.2773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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